October 27, 1914

Washington University Record, October 27, 1994

Addendum, Vol. 13, October 27 Release

[Addendum to the article DOI: 10.5888/pcd13.160232.].

Database Searching and BLAST Tuesday , October 27 th

The goal of a database search is to find all “high-scoring” local alignments (i.e, local alignments with a score above a given threshold) and to determine the significance of alignments found. A database search can be used to compare a protein or a cDNA sequence with genomic DNA, e.g. to find gene location or identify intron/exon boundaries. Another application is to find homologous protein seq...

Dmd053199 1914..1922

Naturally occurring furanocoumarin compounds psoralen (PRN) and isopsoralen (IPRN) are bioactive constituents found in herbaceous plants. They are widely used as active ingredients in several Chinese herbal medicines. In this study, the CYP1A2 inhibitory potential of PRN and IPRN was investigated in rats in vitro and in vivo as well as in human liver microsomes. Both compounds exhibited reversi...

Max Perutz (1914–2002)

Become a scientist, Ernest Rutherford would urge his friends, for then you will never be old, you will remain all your life a child at play. So it proved for the evergreen Max Perutz, who did his last experiment only weeks before he died at the fine age of eighty-seven. Perutz embraced Noël Coward's dictum that 'work is fun, work is much more fun than fun'. In an eventful life, beset in its ear...